A Review of Mathematical Models for Muscular Dystrophy
Amanda Cameron (August 11, 2016)
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Muscular dystrophy (MD) disease dynamics are characterized by structural and functional perturbations that perpetuate disease progression. Developing mathematical models to understand and treat MD involves the integration of previously established immunological and mechanical representations of these factors that bolster disease progression. In this article, we review these models as well as examine key molecular and cellular perspectives to better understand MD's pathogenesis and subsequent progression. Molecular factors that contribute to MD include mitochondrial and genetic components; both drive cellular metabolism, communication and signaling. Furthermore, these molecular factors leave cells vulnerable to mechanical stress which can activate an immunological cascade that can weaken cells and surrounding tissues. This review article provides an essential, brief, biological background for mechanisms modeled. Given the application of developed immunological and molecular models to a wider variety of neurodegenerative diseases linked by related mitochondrial and genetic deficits, understanding and modeling MD is highly applicable.