The Bone Ecosystem and its Influence on Cancer Evolutionary Dynamics

David Basanta (November 4, 2019)

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Abstract

Cancer evolutionary dynamics result from the interplay between a heterogeneous tumor and the ecosystem which it inhabits. While beautiful work has shed light on the role of intra tumor heterogeneity and experimental techniques have allowed us to reconstruct the genetic paths that a cancer has followed in a patient, precious little has been done in understanding eco-evolutionary dynamics in cancer. In our group we have use mathematical and computational tools, integrating experimental data and challenged with clinical data, to study the bone ecosystem and its role in explaining the growth and progression of tumors. This will allow us to understand the interplay between the tumor and the bone, how that shapes its evolutionary dynamics and how treatments could be designed that take that into account.