A stochastic model for enzyme clustering in glucose metabolism

Hye-Won Kang (May 6, 2020)

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Abstract

A sequence of metabolic enzymes tightly regulates glycolysis and gluconeogenesis. It has been hypothesized that these enzymes form multienzyme complexes and regulate glucose flux. In the previous work, it was identified that several rate-limiting enzymes form multienzyme complexes and control the direction of glucose flux between energy metabolism and building block biosynthesis. A recent study introduced a mathematical model to support this finding, in which the association of the rate-limiting enzymes into multienzyme complexes in included. However, this model did not fully account for dynamic and random movement of the enzyme clusters, as observed in the experiment.

In this talk, I will introduce a stochastic model for enzyme clustering in glucose metabolism. The model will describe both the enzyme kinetics and the spatial organization of metabolic enzyme complexes. Then, I will discuss underlying model assumptions and approximation methods.