Joshua Schiffer

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  Anti-Proliferative Therapy for HIV Cure
  Joshua Schiffer

  Despite decades of antiretroviral therapy, replication competent HIV persists in roughly 10 million cells. Using several modeling approaches, we demonstrate that cellular proliferation, rather than low levels of viral replication, is the most critical generative mechanism for persistence of infected cells. We then demonstrate that proliferation may serve as the optimal therapeutic target for reservoir reduction, and describe an ongoing clinical trial to test this hypothesis.